Reduced Creatine Kinase
Reduced creatine kinase is a promising biomarker. posted 08-04-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=670
Sirtuin Inhibition Achieves Neuroprotection by Decreasing Sterol Biosynthesis
SIRT2 inhibition emerges as a promising therapeutic strategy. posted 07-25-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=669
Cargo Recognition is Impaired in HD
Autophagy increases but is impaired, leading to an increase of the HD protein in the cytosol. posted 05-24-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=667
Neurosearch Amends the ACR-16 Results
Statistical significance not achieved on primary endpoint. posted 05-24-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=668
Early Pre-Huntington's Symptoms?
The question of when “onset” occurs has always been a hard one to answer. People in HD families have known for many years that their loved ones' deterioration with HD occurred years before the doctors would or could diagnose it. Our HD does not become real to the medical world until the day we are diagnosed as symptomatic. posted 05-05-2010
http://www.hdac.org/features/article.php?p_articleNumber=665
CoQ10 and Minocycline not helpful in Mouse Model
Neither CoQ10 nor minocycline were helpful in the R6/2 mouse and high doses of minocycline resulted in decreased survival time. posted 04-14-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=664
The European trial of ACR16 yields good results
ACR16 improves voluntary and involuntary movement. This is wonderful news! posted 02-03-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=662
A Sirtuin Inhibitor Enters Phase1a Clinical Trials in Europe
Siena Biotech announces a safety and tolerability study with healthy volunteers, preparatory to trials in HD patients. posted 01-31-2010
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=661
Invitation to participate in a quality of life survey
Here is an opportunity to tell the medical professionals about quality of life issues. posted 12-22-2009
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=659
Synaptic activity, aggregation, and memantine
Dr. Michael Hayden and Dr. Stuart Lipton show that normal synaptic activity is neuroprotective, that extrasynaptic activity is toxic, and that memantine will suppress the later while leaving the former unaffected. posted 12-22-2009
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=651
An interview with Dr. Jan Nolta
A trial of mesenchymal stem cell is planned for the end of 2010. posted 12-06-2009
http://www.hdac.org/features/article.php?p_articleNumber=657
An interview with Dr. Jan Nolta
A trial of mesenchymal stem cell is planned for the end of 2010. posted 12-06-2009
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=657
The RCAN1 gene and HD
Overexpression of the RCAN1 gene may be a treatment for Huntington's Disease. posted 12-05-2009
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=630
The search for genetic modifiers
The search for genetic modifiers is an important part of the effort to find treatments. posted 12-05-2009
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=652
Track-HD reports baseline findings
Baseline findings indicate clear differences that fall on a continuum from the control group to gene carriers predicated to be farther from onset, carriers closer to onset, those in very early stages, and those somewhat later in progression. posted 12-05-2009
http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=653
— news list provided by hdac.org —