DRP1 is Identified as a Promising Therapeutic Target
by Marsha L. Miller, Ph.D. on -0-3--2011 is Published for Science & Research
The HD protein interacts abnormally with the mitochondrial fission GTPase dynamin-related protein-1 (DRP1).
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A Drug in Trials for MS Helps the HD Mice
by Marsha L. Miller, Ph.D. on -0-3--2011 is Published for Science & Research
Dimethylfumarate (DMF) is neuroprotective in two mouse models of Huntington's disease.
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A New Drug Enhances Neural Growth Factor
by Marsha L. Miller, Ph.D. on -0-3--2011 is Published for Science & Research
CeNeRx has a new drug which may have potential to treat Huntington's disease.
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Novel Benzoxazine Compounds
by Marsha L. Miller, Ph.D. on -0-3--2011 is Published for Science & Research
Researchers from Southern Methodist University and the University of Texas at Dallas have collaborated to develop new benzoxazine compounds to prevent neurodegeneration.
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University of Massachusetts Medical School and Lundbeck collaborate to develop RNAi
by Marsha L. Miller, Ph.D. on -0-2--2011 is Published for Science & Research
A preclinical study of allele specific RNAi could prepare the way for clinical trials.
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The Effects of Huntington's
by Kelly B. on -0-2--2011 is Published for HD Family Life
Having HD can and does make my life extremely complicated. Everyday things that can come easily to other people can become a huge struggle.
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Everolimus Not Neuroprotective in the R6/2 mice
by Marsha L. Miller, Ph.D. on -0-1--2011 is Published for Science & Research
A rapamycine derivative improves muscles but does not protect the brain.
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The American ACR16 trial results
by Marsha L. Miller, Ph.D. on -0-1--2011 is Published for Science & Research
The results of the HART trial are encouraging but not conclusive.
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Metalloproteinases
by Marsha L. Miller, Ph.D. on -0-1--2011 is Published for Science & Research
Buck Institute researchers identify promising new targets.
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Autophagy and Antioxidants
by Marsha L. Miller, Ph.D. on -0-1--2011 is Published for Science & Research
Some antioxidants interfere with autophagy, an alternate way to clear away unwanted proteins.
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2010 HDSA Covention Research Forum
by Marsha L. Miller, Ph.D. and Steve Ireland on -0-1--2011 is Published for Science & Research
More from the convention!
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HDSA Convention Session: Potential New Therapies
by Marsha L. Miller, Ph.D. on -0-1--2011 is Published for Science & Research
I'm catching up on updates!
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The Research Pipeline - taking drugs from the lab to the clinic
by Marsha Miller, Ph.D. and Steve Ireland on -1-0--2010 is Published for Science & Research
Here's an overview of some of the more promising potential treatments moving through the research pipeline.
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Reduced Creatine Kinase
by Marsha L. Miller, Ph.D. on -0-8--2010 is Published for Science & Research
Reduced creatine kinase is a promising biomarker.
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Sirtuin Inhibition Achieves Neuroprotection by Decreasing Sterol Biosynthesis
by Marsha L. Miller, Ph.D. on -0-7--2010 is Published for Science & Research
SIRT2 inhibition emerges as a promising therapeutic strategy.
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Neurosearch Amends the ACR-16 Results
by Marsha L. Miller, Ph.D. on -0-5--2010 is Published for Science & Research
Statistical significance not achieved on primary endpoint.
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Cargo Recognition is Impaired in HD
by Marsha L. Miller, Ph.D. on -0-5--2010 is Published for Science & Research
Autophagy increases but is impaired, leading to an increase of the HD protein in the cytosol.
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Early Pre-Huntington's Symptoms?
by Kelly B. on -0-5--2010 is Published for HD Family Life
The question of when “onset” occurs has always been a hard one to answer. People in HD families have known for many years that their loved ones' deterioration with HD occurred years before the doctors would or could diagnose it. Our HD does not become real to the medical world until the day we are diagnosed as symptomatic.
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CoQ10 and Minocycline not helpful in Mouse Model
by Marsha L. Miller, Ph.D. on -0-4--2010 is Published for Science & Research
Neither CoQ10 nor minocycline were helpful in the R6/2 mouse and high doses of minocycline resulted in decreased survival time.
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The European trial of ACR16 yields good results
by Marsha L. Miller, Ph.D. on -0-2--2010 is Published for Science & Research
ACR16 improves voluntary and involuntary movement. This is wonderful news!
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