Reduced Creatine Kinase
by Marsha L. Miller, Ph.D. on 08-04-2010 is Published for Science & Research
Reduced creatine kinase is a promising biomarker.
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Sirtuin Inhibition Achieves Neuroprotection by Decreasing Sterol Biosynthesis
by Marsha L. Miller, Ph.D. on 07-25-2010 is Published for Science & Research
SIRT2 inhibition emerges as a promising therapeutic strategy.
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Neurosearch Amends the ACR-16 Results
by Marsha L. Miller, Ph.D. on 05-24-2010 is Published for Science & Research
Statistical significance not achieved on primary endpoint.
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Cargo Recognition is Impaired in HD
by Marsha L. Miller, Ph.D. on 05-24-2010 is Published for Science & Research
Autophagy increases but is impaired, leading to an increase of the HD protein in the cytosol.
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Early Pre-Huntington's Symptoms?
by Kelly B. on 05-05-2010 is Published for HD Family Life
The question of when “onset” occurs has always been a hard one to answer. People in HD families have known for many years that their loved ones' deterioration with HD occurred years before the doctors would or could diagnose it. Our HD does not become real to the medical world until the day we are diagnosed as symptomatic.
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CoQ10 and Minocycline not helpful in Mouse Model
by Marsha L. Miller, Ph.D. on 04-14-2010 is Published for Science & Research
Neither CoQ10 nor minocycline were helpful in the R6/2 mouse and high doses of minocycline resulted in decreased survival time.
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The European trial of ACR16 yields good results
by Marsha L. Miller, Ph.D. on 02-03-2010 is Published for Science & Research
ACR16 improves voluntary and involuntary movement. This is wonderful news!
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A Sirtuin Inhibitor Enters Phase1a Clinical Trials in Europe
by Marsha L. Miller, Ph.D. on 01-31-2010 is Published for Science & Research
Siena Biotech announces a safety and tolerability study with healthy volunteers, preparatory to trials in HD patients.
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Family
by Kelly B. on 01-01-2010 is Published for HD Family Life
Huntington’s Disease is a whole family affair. There are many sad stories, but there are just as many people out there who are fighting their own HD dragon with a bravery that makes their family and friends proud.
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Synaptic activity, aggregation, and memantine
by Marsha L. Miller, Ph.D. on 12-22-2009 is Published for Science & Research
Dr. Michael Hayden and Dr. Stuart Lipton show that normal synaptic activity is neuroprotective, that extrasynaptic activity is toxic, and that memantine will suppress the later while leaving the former unaffected.
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Invitation to participate in a quality of life survey
by Marsha L. Miller, Ph.D. on 12-22-2009 is Published for Science & Research
Here is an opportunity to tell the medical professionals about quality of life issues.
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An interview with Dr. Jan Nolta
by Marsha L. Miller, Ph.D. on 12-06-2009 is Published for Science & Research
A trial of mesenchymal stem cell is planned for the end of 2010.
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Mesenchymal stem cells repair neurotoxin damage in an animal model
by Marsha L. Miller, Ph.D. on 12-05-2009 is Published for Science & Research
Preclinical work supports the use of mesenchymal stem cells to treat neurodegenerative disorders.
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Cogane
by Marsha L. Miller, Ph.D. on 12-05-2009 is Published for Science & Research
A new BDNF inducer enters the pipeline.
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Track-HD reports baseline findings
by Marsha L. Miller, Ph.D. on 12-05-2009 is Published for Science & Research
Baseline findings indicate clear differences that fall on a continuum from the control group to gene carriers predicated to be farther from onset, carriers closer to onset, those in very early stages, and those somewhat later in progression.
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The search for genetic modifiers
by Marsha L. Miller, Ph.D. on 12-05-2009 is Published for Science & Research
The search for genetic modifiers is an important part of the effort to find treatments.
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The RCAN1 gene and HD
by Marsha L. Miller, Ph.D. on 12-05-2009 is Published for Science & Research
Overexpression of the RCAN1 gene may be a treatment for Huntington's Disease.
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Sub Cortical Front Dementia in Huntington's Disease
by Phil Hardt on 11-01-2009 is Published for HD Family Life
There is a very pressing need to frankly discuss one of the most debilitating symptoms in the neuropsychiatric sequelae of “softer” symptoms in Huntington’s Disease- sub-cortical “frontal” dementia.
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Axonal transport impaired in HD
by Marsha L. Miller, Ph.D. on 09-23-2009 is Published for Science & Research
Researchers have identified the mechanism by which axonal transport is impaired in neurons in HD.
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Managing Medications from a Caregiver's Perspective
by Dave Kendall on 09-20-2009 is Published for HD Family Life
Medications are one of the most difficult issues facing Huntington’s Disease (HD) caregivers and patients
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