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The focus of HDAC is on helping others understand what the experience of Huntington's Disease familes is like, caregiving, and advocacy.
Our sister site, the HD Lighthouse is where we focus on research and the progress
in treatments and clinical trials.
The information posted here are links to articles that highlight significant advances in the treatment of HD, updates to the HD Lighthouse,
and updates to HDAC.
Recently we began offering an RSS feed. RSS stands for Really Simple Syndication and that simply means that instead of you bouncing around
the Internet trying to find out what's been updated, we will instead tell you when something has changed. I use Thunderbird as my email client
and it has RSS capabilities built in. So I can add a new email account and link it to an RSS feed. So when a Web page is updated it is fed
as a new email directly to my email account so that I can open the email and go directly to the Web page - pretty cool stuff.
- The European trial of ACR16 yields good results [HDlighthouse.org]
- A Sirtuin Inhibitor Enters Phase1a Clinical Trials in Europe [HDlighthouse.org]
- Invitation to participate in a quality of life survey [HDlighthouse.org]
- Synaptic activity, aggregation, and memantine [HDlighthouse.org]
- An interview with Dr. Jan Nolta [HDAC.org]
- An interview with Dr. Jan Nolta [HDlighthouse.org]
- The RCAN1 gene and HD [HDlighthouse.org]
- The search for genetic modifiers [HDlighthouse.org]
- Track-HD reports baseline findings [HDlighthouse.org]
- Cogane [HDlighthouse.org]
- Mesenchymal stem cells repair neurotoxin damage in an animal model [HDlighthouse.org]
- Sub Cortical Front Dementia in Huntington's Disease [HDAC.org]
- Managing Medications from a Caregiver's Perspective [HDAC.org]
- Axonal transport impaired in HD [HDlighthouse.org]
- Using Your Words [HDAC.org]
- --- end of entries loaded into RSS feed ---
- Creatine and CoQ10 [HDlighthouse.org]
- Rhes and the HD protein [HDAC.org]
- Rhes and the HD protein [HDlighthouse.org]
- Medivation to begin a Phase III trial of Dimebon [HDlighthouse.org]
- Relocating [HDAC.org]
- Advocacy opportunity for Stem Cell Research [HDAC.org]
- Letter to President Obama on H.R. 678 [HDAC.org]
- An ampakine upregulates BDNF [HDlighthouse.org]
- Acetylation of the HD protein [HDlighthouse.org]
- Disappointing results from a Phase II trial of CERE-120 for PD patients [HDlighthouse.org]
- CERE-120 (AAV-Neurturin) is neuroprotective in HD mouse model [HDlighthouse.org]
- Minocycline Phase II clinical trial results are disappointing [HDlighthouse.org]
- A Day on Capitol Hill [HDAC.org]
- Toxic HD protein fragments [HDlighthouse.org]
- Amarin files new drug application for AMR 101 in Europe [HDlighthouse.org]
- A Day in the Life, an HD Experience, Charlotseville, VA, April 18th [HDAC.org]
- Warning about Reglan [HDlighthouse.org]
- Confronting Fate [HDAC.org]
- Surprising Finding Points to Possible Treatment for Huntington Disease [HDlighthouse.org]
- Impaired ERAD and ER stress [HDlighthouse.org]
- PGC-1 alpha gene downregulated in HD [HDlighthouse.org]
- PGC-1 alpha gene modifies age of onset in HD [HDlighthouse.org]
- Weight loss in HD [HDlighthouse.org]
- Long term tetrabenazine use [HDlighthouse.org]
- My First Christmas in Heaven [HDAC.org]
- Faith [HDAC.org]
- Ethyl-EPA research report published [HDlighthouse.org]
- The HD protein activates Nrf-2 responsive genes [HDlighthouse.org]
- My Friend, My Hero, My Lorna [HDAC.org]
- Ethyl-EPA reduces cerebral atrophy in HD patients [HDlighthouse.org]
- Using the Neuropsychological Exam and Other Tools To Help Those Struggling With the “Softer” Symptoms of Huntington’s Disease [HDAC.org]
- A new HDAC inhibitor [HDlighthouse.org]
- Cytochrome c release as a therapeutic target [HDlighthouse.org]
- mRNA levels of BDNF in rodent models of HD [HDlighthouse.org]
- Why did CEP-1347 fail in the Parkinson′s trial? [HDlighthouse.org]
- CEP-1347 restores BDNF expression in the R6/2 mice [HDlighthouse.org]
- A strict Mediterranean diet can help reduce deaths from major chronic diseases [HDlighthouse.org]
- The HSC National Conference 2008 [HDAC.org]
- Stress [HDAC.org]
- Extra payments to Medicare Advantage plans to total $8.5 billion in 2008 [HDAC.org]
- Activation of the immune system in HD [HDlighthouse.org]
- FDA approves tetrabenazine [HDlighthouse.org]
- Ritalin and JHD - a case study [HDlighthouse.org]
- Class of antibiotics enhances RNAi [HDlighthouse.org]
- The FDA approves a Phase IIB clinical trial for ACR16 [HDlighthouse.org]
- Altered histone monoubiquitylation and transcriptional dysregulation [HDlighthouse.org]
- Participants needed for qualitative studies of JHD [HDlighthouse.org]
- Encouraging results from the Phase II Dimebon trial [HDlighthouse.org]
- Go outside and enjoy nature! [HDlighthouse.org]
- The HD protein is toxic in the cytoplasm [HDlighthouse.org]
- Patient Power series on Huntington's Disease starting June 2nd [HDAC.org]
- Living Large [HDAC.org]
- Self-Advocacy, Part Two: Documenting Disability [HDAC.org]
- New transgenic rhesus monkey model of HD developed [HDlighthouse.org]
- Dine for Huntington's Disease in Elgin Texas on April 25th [HDAC.org]
- New Insights About Huntingtin Interacting Protein 1 [HDlighthouse.org]
- Exercise helps young HD mice [HDlighthouse.org]
- Early neurotransmitter problems in HD [HDlighthouse.org]
- Approved drugs found to induce autophagy [HDlighthouse.org]
- Living with Huntington's Disease Spring Symposium [HDAC.org]
- 2008 CHDI HD Therapeutics Conference: A Report from an HD Family Perspective [HDlighthouse.org]
- Charles Sabine on Fear, Hope and Dignity [HDDrogworks.org]
- FDA Notifies Public of Adverse Reactions Linked to Botox Use [HDlighthouse.org]
- Anesthesia Warning - Isoflurane [HDlighthouse.org]
- Webcast, Patient Power, to discuss “Huntington’s Disease: Understanding Illnesses of the mind and body,” [HDAC.org]
- So Why Are We Not Exercising? [HDlighthouse.org]
- Fruits and Vegetables Counter Negative Effects of Fats [HDlighthouse.org]
- Zoloft raises BDNF, helps the HD mice [HDlighthouse.org]
- Screening Yields a Promising Compound [HDlighthouse.org]
- The Predict-HD Study Identifies Early Changes [HDlighthouse.org]
- C2-8 Suppresses Neurodegeneration in Drosophilia [HDlighthouse.org]
- C2-8 Slows Progression in HD Mice [HDlighthouse.org]
- To Test or Not to Test: The Elephant in the Picture Window [HDDrugWorks.org]
- Genetic modifiers in drosophilia models of HD and SCA1 [HDlighthouse.org]
- Lack of BDNF and overeating [HDlighthouse.org]
- Can We Get There From Here? ... part 1 [HDSA.org]
- Can We Get There From Here? ... part 2 [HDSA.org]
- Can We Get There From Here? ... Part 3 [HDSA.org]
- The Inaugural HSG Clinical Research Was a Success [HDSA.org]
- Buck Institute and Neurobiological Technologies, Inc. Partner to Develop Treatment for HD [HDlighthouse.org]
- A New Era for Stem Cells [HDDrugWorks.org]
- Miraxion results look promising [HDlighthouse.org]
- Blueberries ... and Walnuts?! [HDlighthouse.org]
- Minocycline accelerates ALS progression [HDlighthouse.org]
- New Virginia Chapter of HDSA is Underway [HDAC.org]
- siRNA Helps a Viral Transgenic Mouse Model of HD [HDlighthouse.org]
- Young People Who Undergo Predictive Testing [HDlighthouse.org]
- CHDI and Intellect Neurosciences to collaborate on testing Oxigon for HD [HDlighthouse.org]
- BDNF, fragile X syndrome, and memory [HDlighthouse.org]
- Boosting BDNF by Listening to Music [HDlighthouse.org]
- ACR16 closer to Phase III clinical trials [HDlighthouse.org]
- Neurogenesis in HD mice prolongs life [HDlighthouse.org]
- What if it's not Huntington's Disease? [HDlighthouse.org]
- Mediterranean diet delays death in Alzheimer's [HDlighthouse.org]
- RE1/NRSE Mediated Gene Transcription [HDlighthouse.org]
- Gene Expression Analysis and Extra-Mitochondrial Energy Metabolism [HDlighthouse.org]
- The Molecular Zip Code Research Yields a Drug Target [HDlighthouse.org]
- Riluzole Found Ineffective for Huntington's Disease Patients [HDlighthouse.org]
- Factors Associated with HD CAG repeat instability in Huntington's disease [HDlighthouse.org]
- Social support in cyberspace [HDlighthouse.org]
- Daniel P. Van Kammen, MD, Phd, to lead CHDI Huntington's Disease Clinical Development Effort [HDlighthouse.org]
- HD Study for Those At Risk [HDlighthouse.org]
- HSG to Conduct a Phase 2 Study in Adults with Mild-to-Moderate Huntington Disease [HDlighthouse.org]
- Gene Therapy Trial Death [HDlighthouse.org]
- Gene therapy patient dies, trial shut down [CNN.org]
- CAG Counts Unrelated to Psychiatric Symptoms in HD. [HDlighthouse.org]
- Summer Saturday for Families at the Guthrie Center on July 28th [HDAC.org]
- Low BDNF levels in serum of HD patients. [HDlighthouse.org]
- Psychiatric and Cognitive Difficulties as Indicators of JHD [HDlighthouse.org]
- High Q and Stem Cell Innovations, Inc. to Collaborate [HDlighthouse.org]
- Parkinson's and Gene Therapy [HDlighthouse.org]
- Parkinson's, Sirtuin2 and Drug Development [HDlighthouse.org]
- Research Update from the 2007 HDSA convention: Part Two [HDlighthouse.org]
- Research Update from the 2007 HDSA Convention: Part One [HDlighthouse.org]
- DNA Repair and HD [HDlighthouse.org]
- Toward a treatment of cognitive/behavioral symptoms with BDNF [HDlighthouse.org]
- Quality of life: patients and partners [HDlighthouse.org]
- D1 receptors and HD [HDlighthouse.org]
- Quality of life: patients and partners [HDlighthouse.org]
- Protein Interactions [HDlighthouse.org]
- Zorro-LNA: A New Way to Turn off Genes [HDlighthouse.org]
- Fats in the Diet [HDAC.org]
- Hitler's 'Cure' for Huntington's Disease [HDAC.org]
- Clioquinol helps the R6/2 mouse [HDlighthouse.org]
- Copper in the HD brain [HDlighthouse.org]
- Curcumin in a toxin model of HD [HDlighthouse.org]
- Young Adults Can Tell It Like It WAS! [HDlighthouse.org]
- Long Journey Home [HDAC.org]
- Drugs for HD: A Best Case Scenario [HDDrugWorks.org]
- Adenosine A(2A) Receptors in Huntington's disease [HDlighthouse.org]
- A Report on the 2007 HD Therapeutics Conference [HDlighthouse.org]
- Further Evidence that Trehalose may be Beneficial for HD. [HDDrugWorks.org]
- HDDW Trials at 2 1/2 Years and the Stockdale Paradox [HDDrugWorks.org]
- Loneliness and Dementia [HDlighthouse.org]
- NCAMs in the HD mice [HDlighthouse.org]
- Miraxion Study Completed, Results Soon [HDlighthouse.org]
- HSG Press Conference - January 2007 [HDlighthouse.org]
- JHD Retreat in Arizona June 1-3 [HDAC.org]
- Yes, There is Such a Thing as a Free Lunch! [HDAC.org]
- Advocate for the Genetic Information Nondiscrimination Act of 2007 [HDAC.org]
- Families discuss preclinical HD [HDlighthouse.org]
- Tony, Me, and Healthy Cooking [HDAC.org]
- Creatine trials [HDlighthouse.org]
- Striosome Damage Indicted in HD Mood Disorders [HDlighthouse.org]
- Psychiatric Disorders in Pre-Clinical Huntington's disease [HDlighthouse.org]
- Clinical Trial of Stem Cell Therapy for Batten Disease [HDlighthouse.org]
- A New Study Finds Minocycline to be Ineffective in the N171-82Q Mouse Model [HDlighthouse.org]
- Minocycline Blocks PARP-1 [HDlighthouse.org]
- Stem Cells and The Aging Brain [HDlighthouse.org]
- CHDI Selects ENKAM’s Compounds for Preclinical Testing [HDlighthouse.org]
- Help for Huntington's [HDAC.org]
- HDL:Teens needed for survey []
- HDL:ReNeuron Files Application with FDA to Begin Phase I Study of Stem Cell Treatment for Stroke Patients. []
- HDL:Overexpressing Normal Huntington's Slightly Beneficial in a Mouse Model []
- HDL:Huntington Study Group 2006 Annual Meeting Report []
- HDL:A pilot study of the clinical efficacy and safety of memantine for Huntington's disease. []
- HDL:Parents and JHD []
- HDL:CHDI, MethylGene and HDAC inhibitors []
- HDL:JHD in four patients []
- Attitudes About HD Testing in India [HDlighthouse.org]
- Actor Michael J. Fox Stumps for Candidates and Stem Cell Research in Tempe, Arizona 11/6/06 []
- Bill at the Polls []
- Sarah Barley’s Art Showing at Gallery OneTen – HD Fundraiser []
- HDL:Genetic Testing for Children Who Have JHD Symptoms []
- HDL:Speech delay in JHD []
- HDL:JHD — Literature Review and Case Reports []
- HDL:Benefits of Exercise []
- HDL:Ceregene announces its own promising gene therapy trial for PD patients. []
- HDL:Successful Phase I Gene Therapy Trial with PD patients []
- HDL:Mediterranean Diet Reduces Risk of Alzheimer's []
- HDL:Goodbye control groups? []
- HDL:Predict-HD: Recruiting Gene Negative Individuals []
- Testimony before the Secretary's Advisory Committee on Genetics, Health, and Society []
- HDL:FDA approves safety and tolerability trial for Dimebon []
- HDL:CAG Counts: Intermediate alleles []
- HDL:HD Jails in Juan de Acosta, Colombia - A Tale of Two Families []
- HDL:Ampakines and HD []
- HDL:New Website Brings Latest Clinical Research News to Huntington's Disease Families []
- New Website Brings Latest Clinical Research News to Huntington's Disease Families []
- Organic Denial []
- HDL:Hereditary Disease Foundation meeting: HD 2006: Changes, Advances and Good News (CAG)n []
- HDL:Australian Rare Disease Guidelines for General Practitioners []
- HDL:Peer-Professional Workgroups in Palliative Care []
- HDL:RNA Interference Points Toward Cure of Neurological Diseases []
- HDL:A Better CoQ10 for Huntington's Disease Coming Soon? []
- Living Positively with Huntington’s Disease []
- HDL:Phil Hardt on Social Security Revised []
- HDL:Dystonia-Predominant Adult-Onset Huntington Disease: Association Between Motor Phenotype and Age of Onset in Adults. []
- HDL:HD - Evolution gone wild? []
- HDL:Mice Engineered Without CAG Repeats []
- HDL:Probability of Obsessive and Compulsive Symptoms in Huntington's Disease []
- Life's Regrets []
- HDL:Participating in the PREDICT-HD Study []
- HDL:Preparing for Preventive Clinical Trials: The Predict-HD study []
- HDL:Caspase 6 Resistant HD Mice Do Not Develop the Huntington's Disease []
- 21st Annual Convention of the Huntington’s Disease Society of America []
- HDL:CoQ-10: More is Best []
- HDL:Blueberries Restore Age Related Decline in HSP 70 []
- HDL:Test-Retest Brain Imaging Study []
- HDL:Trophic Factors Generate Functioning New Neurons for Brain Repair []
- HDL:Swedish Company Announces Results of Phase II study of Dopamine Stabilizing Compound []
- HDL:Trehalose: Sweet Rescue []
- HDL:Green Tea is neuroprotective []
- HDL:A Review of the Book Metal-Based Neurodegeneration: From Molecular Mechanisms to Therapeutic Strategies
by Robert Crichton and Roberta Ward []
- HDL:Social interaction is neuroprotective []
- HDL:BDNF Influences the Time of Onset and Severity of Motor Problems in Huntington’s []
- HDL:Running from The Devil []
- HDL:Late stage HD mice recover motor functions after gene silencing []
- HDL:Eat Smart []
- HDL:Buff and Brainy []
- HDL:Discovering the Family History of Huntington Disease (HD). []
- HDL:A Perspective for Treating HD Today []
- HDL:Highlights of the HD Therapeutics Conference []
- 21st Annual HDSA Convention, June 9th []
- HDL: The Channel Hypothesis - Do different degenerative diseases share a common toxic mechanism? []
- HDLighthouse: Treating Myoclonus in HD Patients []
- HDLighthouse: Encouraging News about Tetrabenazine []
- HDLighthouse: Ubiquilin as a New Therapeutic Target in Huntington's Disease []
- Testing Positive for Huntington's Disease []
- HDLighthouse: More evidence that creatine may be an effective treatment for HD []
- HDLighthouse: An update on CHDI, Inc. - The HD Drug Discovery Company []
- HDLighthouse: Mutant huntingtin alters MAPK signalling pathways []
- HDlighthouse: A Clue Regarding Huntingtin Fragments []
- A documentary on Living with HD by Rob Hopping []
- Dolly creator promotes stem cell therapy for those with neuro-degenerative diseases []
- HDlighthouse: Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity []
- HDlighthouse: Huntington Study Group 2005 Annual Meeting Report []
- HDlighthouse: More on SSRIs and BDNF []
- HDlighthouse: Engineered Progenitor Brain Cells Can Be Used To Get Neurotrophins Into The Brain []
- HDlighthouse: Bistability of protein aggregation: Mathematics to the rescue? []
- Milestone: Gene therapy delivers growth factors to PD patients. []
- HDlighthouse: Finally! Proof that Combined Therapy is More Effective than Single Therapy Treatment []
- New Neurons Grow in Mice with Huntington's Disease []
- Scientist receives award for research on brain cell activity. []
- RNAi update - macular degeneration clinical trial going well. []
- Enrollment opens for Miraxion clinical trials []
- Mike O'Brien Dies on Mount Everest while trying to raise money for HD research. []
- U. Iowa Researchers Improve Huntington's Disease Symptoms In Mice []
- MS drug may treat HD; Co-polymer 1 now in Phase II clinical trials for HD. []
- Amarin finalizing protocols for Phase III clinical trials for Miraxion (LAX 101) []
- Curry may be a treatment for HD []
- Here we go - RNAi clinical trials start for macular degeneration []
- Inhibiting the HD protein aggregates []
- Instructor with HD finds that Yoga helps others and herself []
- Arlo to perform with Klezmatics - more insight into Woody Guthrie's legacy. []
- Mike Shay named to ITCCC Hall of Fame []
- Amarin has the financing to move forward with Miraxion clinical trials []
- UK company makes progress with stem cells []
- Milestone - RNAi therapy is being tested in people with macular degeneration []
- Campers with HD Enjoy Annual Camp in Michigan []
- Lax 101(now called Miraxion) is a treatment for HD patients with fewer than 45 CAG repeats []
- NZ researchers to develop a sheep model of HD []
- UK Bike Ride will raise funds for HD []
- More commentary on RNAi interference therapy []
- DNA decipherer Francis Crick dies []
- Jason Ritter advocates for Huntington's Disease research []
- British woman who tested positive for the HD gene to compete in Olympic rowing []
- Geldanamycin arrests neurodegeneration in a fruitfly model []
- The HD protein deactivates the transcription factor TBP []
- CBP, Long Term Memory, and HDAC inhibitors []
- Pharmaceutical companies to invest in HDAC inhibitor research. []
- The Huntingtin's Protein acts as a booster rocket to get BDNF to striatal neurons []
- Portrait of Woody Guthrie to be unveiled in Oklahoma capitol []
- Arlo Guthrie []
- Another interview with Dr. Davidson on RNAi []
- Salk Institute to begin RNA interference therapy with HD mice []
- New findings about the toxicity of the HD protein []
- HD researcher knighted []
- Daughter of Woman with HD to carry the Olympic torch []
- HD stem cell line to be created to aid in basic research []
- Cure Hoped for Huntington's Disease - More on RNAi therapy []
- Sirna Therapeutics Evaluating RNAi to Treat Huntington's Disease []
- A new approach to brain repair for neurodegenerative diseases []
- Major breakthrough - SCA1 mice successfully treated with RNA interference therapy []
- Rapamycin delays onset and progression in the HD mice []
- Progress with other neurodegenerative disorders []
- Simple sugar eases Huntington's disease in mice []
- Antidepressants stimulate the growth of new neurons in mice []
- Dancer with HD to perform in the Berkshires. []
- Calcium channel problem implicated in neuron death in HD []
- Progress on Gene Silencing []
- Congo red dye could be a treatment for HD []
- New Gene Therapy Approach looks Promising []
- LAX 101 results are in! []
- Treatable Psychiatric Symptoms Common With Degenerative Brain Disease []
- Bile Acid Inhibits Cell Death in HD Mice []
- Nerve Cells' Death Different From Other Cells' []
- New signaling pathway found, link to HD? []
- Antioxidant rich diets []
- A Deadly Disease Destroys Families as Well as Patients []
- UW athlete knows the odds and grabs her chance at life. []
- Stanford students develop new HD web site []
- Complete Genome Map by 2003 []
- Protein That Halts Huntington's Disease Found []
- Cystamine helps HD mice []
- HD Protein Blocked in Cultured Cells []
- Clearing toxic clumps from the brain []
- Rethinking the disease process. []
- brain cell transplantation: new technology []
- Cell Death []
- Treatment for Tardive Dyskinesia? []
- HD & Cell Communication []
- More on BDNF - growth of new neurons []
- Australia gets stem cell research center []
- Stem Cell Research []
- CARE-HD results []
- New research technique: proteome chips []
- NINDS, HDSA, & HDF partner to facilitate drug screening to find new treatments []
- Finding may lead to new approaches for treating brain and spinal cord []
- Types of cell death []
- Italian discovery may suggest a new approach for developing therapy []
- HD aggregates countered with an intracellular antibody in a cell model of HD []
- Superman Sues to Continue Stem Cell Research []
- Protein Aggregates ARE harmful []
- Angels on Wheels (Border War on HD) []
- HUNT-DIS Award Winner Announced []
- Brain Tissue Donation for HD Research []
- Gene Therapy & Safety []
- Brain tumors treated with antisense therapy (a technique being researched for HD) []
- Coenzyme Q10 May Benefit Some Patients With Familial Cerebellar Ataxia []
- Time Perception Impaired in HD []
- Hopkins Scientists Discover How Huntington's Kills Cells: Block Death In Cultures []
- Christian Activists File Suit To Stop Embryonic Stem Cell Research []
- Running Boosts Brain Cell Numbers In Neurodegenerative Disease Model []
- Loss of cortical and thalamic neuronal tenascin-C expression! []
- At Risker's Retreat in April! []
- Parkinson's Cure May be Near []
- Fetal Cell Transplants Show Promise []
- Support Stem Cell Research []
- Two thirds of Americans favor stem cell research []
- The Genetics of Huntington's Disease (an interview with Dr. Nance) []
- Stem Cells Stimulated By Natural Growth Factor Reverse Damage, Restore Some Function In Adult Brain []
- ustained Use Of Anti-Depressants Increases Cell Growth And Protects Cells In The Brain []
- Turning Blood Into Brain []
- Dr. Horrobin Addresses HDA Conference regarding EPA []
- Preimplantation Genetic Diagnosis: The Next Big Thing? []
- New genes implicated in neurodegenerative diseases []
- Gene Therapy Shown To Protect And Reverse The Debilitating Effects Of Parkinson's Disease In Pre-Cli []
- Gene Therapy Rescues Brain Cells In Parkinson's Model []
- Fish Oil Supplement containing EPA is a possible treatment for HD []
- Protein Chips Offer Powerful Method for Probing Protein Function []
- Power to the People []
357 announcements listed.
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