HDAC & HDL Updates Copyright (c) 2007 HDAC. All rights reserved.Recent HD News and updates from HDLighthouse.org http://www.hdac.org/news/ Sun, 6 Feb 2011 20:39:39 -0600 University of Massachusetts Medical School and Lundbeck collaborate to develop RNAi [HDlighthouse.org] A preclinical study of allele specific RNAi could prepare the way for clinical trials. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=677 Sun, 6 Feb 2011 12:01:02 -0600 The Effects of Huntington's [HDAC.org] Having HD can and does make my life extremely complicated. Everyday things that can come easily to other people can become a huge struggle. http://www.hdac.org/features/article.php?p_articleNumber=678 Tue, 1 Feb 2011 12:01:02 -0600 Metalloproteinases [HDlighthouse.org] Buck Institute researchers identify promising new targets. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=673 Thu, 20 Jan 2011 12:01:02 -0600 The American ACR16 trial results [HDlighthouse.org] The results of the HART trial are encouraging but not conclusive. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=675 Thu, 20 Jan 2011 12:01:02 -0600 Everolimus Not Neuroprotective in the R6/2 mice [HDlighthouse.org] A rapamycine derivative improves muscles but does not protect the brain. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=676 Thu, 20 Jan 2011 12:01:02 -0600 2010 HDSA Covention Research Forum [HDlighthouse.org] More from the convention! http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=672 Wed, 19 Jan 2011 12:01:02 -0600 Autophagy and Antioxidants [HDlighthouse.org] Some antioxidants interfere with autophagy, an alternate way to clear away unwanted proteins. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=674 Wed, 19 Jan 2011 12:01:02 -0600 Reduced Creatine Kinase [HDlighthouse.org] Reduced creatine kinase is a promising biomarker. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=670 Wed, 4 Aug 2010 12:01:02 -0500 Sirtuin Inhibition Achieves Neuroprotection by Decreasing Sterol Biosynthesis [HDlighthouse.org] SIRT2 inhibition emerges as a promising therapeutic strategy. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=669 Sun, 25 Jul 2010 12:01:02 -0500 Cargo Recognition is Impaired in HD [HDlighthouse.org] Autophagy increases but is impaired, leading to an increase of the HD protein in the cytosol. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=667 Mon, 24 May 2010 12:01:02 -0500 Neurosearch Amends the ACR-16 Results [HDlighthouse.org] Statistical significance not achieved on primary endpoint. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=668 Mon, 24 May 2010 12:01:02 -0500 Early Pre-Huntington's Symptoms? [HDAC.org] The question of when “onset” occurs has always been a hard one to answer. People in HD families have known for many years that their loved ones' deterioration with HD occurred years before the doctors would or could diagnose it. Our HD does not become real to the medical world until the day we are diagnosed as symptomatic. http://www.hdac.org/features/article.php?p_articleNumber=665 Wed, 5 May 2010 12:01:02 -0500 CoQ10 and Minocycline not helpful in Mouse Model [HDlighthouse.org] Neither CoQ10 nor minocycline were helpful in the R6/2 mouse and high doses of minocycline resulted in decreased survival time. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=664 Wed, 14 Apr 2010 12:01:02 -0500 The European trial of ACR16 yields good results [HDlighthouse.org] ACR16 improves voluntary and involuntary movement. This is wonderful news! http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=662 Wed, 3 Feb 2010 12:01:02 -0600 A Sirtuin Inhibitor Enters Phase1a Clinical Trials in Europe [HDlighthouse.org] Siena Biotech announces a safety and tolerability study with healthy volunteers, preparatory to trials in HD patients. http://www.hdlighthouse.org/showUpdate.php?p_articleNumber=661 Sun, 31 Jan 2010 12:01:02 -0600